Oxidative stress is essentially an imbalance between the production of free radicals and the body’s ability to counteract their potential negative effects. Blockage of oxidative stress is achieved through the action of antioxidant substances, which the body generates itself or which are administered externally.
Changes in the normal redox state of cells can cause cell toxicity, induced directly by the reactive oxygen, or from its derivatives like superoxide radicals, hydroxyl radicals or peroxides. These types of molecules can generate damage to all cell components–proteins, lipids, and DNA–if not offset by specific antioxidant action.
The human spermatozoon is highly susceptible to oxidative stress. Peroxidative damage directly affects the lipid component of the membrane and also generates breaks in the chains of both nuclear and mitochondrial DNA.
Applications of Oxisperm®
- Oxisperm®, for its clinical application, is an easy-to-perform and reliable assay that allows the measurement of potential excess superoxide anions present in the ejaculate, with a minimum volume of sperm.
- Determination of oxidation levels in the ejaculate and reanalysis after treatment with antioxidants.
- Evaluation of the oxidation in each patient to select the best sample that can be presented.